WWOX Polyclonal Antibody
簡要描述:WWOX Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應(yīng)性: Human;Mouse應(yīng)用: WB;IHC;IF;ELISA
產(chǎn)品型號: YP-Ab-00549
所屬分類:多克隆抗體
更新時間:2024-11-01
詳細說明:
WWOX Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),是一種能特異性結(jié)合抗原的糖蛋白,而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi),抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據(jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū),為抗原結(jié)合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結(jié)構(gòu)上的差異),每一個抗體的重鏈則決定了它的類或型。
產(chǎn)品詳情
WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
免疫原詳細信息
The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
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備注:圖片僅供參考。僅供科研,不可用于臨床。